Explore the proteome
We’ve designed our proprietary library of non-covalent chemical probes for diversity. When coupled with our advanced chemoproteomics platform and sophisticated informatics, we gain the unique ability to define probe-protein interactions on a global scale, revealing novel druggable pockets across a complete range of mechanisms, including active sites, allosteric sites, and protein-protein interactions.
Capture high-value targets
We take target-centric and phenotypic-based approaches with our unique, expansive, and expanding library of universal affinity probes designed for diversity in drug-like space. Chemoproteomics-enabled targeted profiling and phenotypic screening represent powerful orthogonal approaches for the discovery of tractable ligands against high-value protein targets, with either genetic and/or pharmacological validation linking them to human pathophysiology. These include not just enzymes but transcription factors, channels, transporters, receptors, chaperones, uncharacterized proteins, and more.
Define the binding site
Our screening platform enables concurrent identification of binding sites within protein targets, accelerating an understanding of the mechanism of action, and facilitating structure-based drug design and downstream medicinal chemistry efforts.